Chelsea Handler is the television host of her own late night talk show "Chelsea Lately", which airs on the E! network weeknights at 11:30pm. "Chelsea Lately" was first broadcast in July of 2007 and quickly became a hit with Chelsea Handler's trademark blend of sarcasm and commentary on everything from politics to celebrity culture, averaging over half a million viewers.

In October of 2008, it was announced that the program was renewed by E! and will run until 2009. The show's format opens with a roundtable of 3 guests, followed by one-on-one interviews with actors and comedians, in addition to off-the-wall, humorous sketches. Recent guests have included Lance Bass, Jenny McCarthy, and Tom Bergeron, among others.

Although she is currently best known for "Chelsea Lately", Chelsea Handler is also a comedian, actress, writer and author, with two books that have made it onto the New York Times Best Seller List. "My Horizontal Life: A Collection of One-Night Stands" was written as a memoir in June of 2005, with a compilation of humorous essays titled "Are You There Vodka? It’s Me Chelsea" following in 2008.

Chelsea Handler has performed all over the country as a stand-up comedian, most recently as a member of the "Hour Stand-Up Comedy Tou" cast, and her comedy can be seen on VH1, Comedy Central, and HBO. She has made guest appearances on a variety of television programs, including "Girls Behaving Badly", "The Practice", "Weekends at the D.L.", "The View", "Red Eye with Greg Gutfeld", and "The Bernie Mac Show".